Valproic acid and gingival disorders
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چکیده
Introduction Valproic acid (Depakine ) is an anti-epileptic drug which is indicated for the treatment of primary generalized epilepsy, partial epilepsy, with focal and psychomotoric symptoms and secondary forms of generalized epilepsia. The mechanism of action of valproic acid has not yet been established, the activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA). Furthermore valproic acid may act on the GABA receptor itself. The most commonly reported adverse drug reactions of valproic acid are gastrointestinal symptoms like nausea, vomiting and diarrhoea. In the SmPC of valproic acid, stomatitis is mentioned as adverse effect. Adverse effects on the gingival tissue are not described [1]. The current observation describes the association between valproic acid and gingival disorders.
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